Effect of secretin and cholecystokinin-pancreozymin
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چکیده
The inhibition of gastric motility induced by placing fat in the duodenum was demonstrated to be humoral by Farrell and Ivy (1926). Subsequent studies on extracts of duodenal mucosa have failed to define the substance involved, although the concept that 'enterogastrone' is a duodenal hormone inhibiting both gastric motility and acid secretion is accepted (Grossman, 1950). In recent years, specific extracts of duodenal mucosa containing cholecystokinin, secretin, and pancreozymin activity (Jorpes and Mutt, 1959) have been prepared. One of these preparations containing secretin was found to inhibit gastric acid secretion (Greenlee, Longhi, Guerrero, Nelsen, El Bedri, and Dragstedt, 1957). This work was later confirmed with the improved duodenal extracts currently available (Wormsley and Grossman, 1964). Recently extracts containing cholecystokinin-pancreozymin activity were also found to inhibit gastric acid secretion and to exceed secretin preparations in potency (Gillespie and Grossman, 1964; Jordan and De la Rosa, 1965). In the study of duodenal extracts and their relation to gastric motor activity, it is noteworthy that one of the first preparations used to duplicate the action of fat in the duodenum was an extract containing cholecystokinetic activity (Kosaka and Lim, 1930). Current studies in this laboratory have demonstrated gastric motor inhibition in denervated fundic pouches and innervated stomachs of dogs by intravenous infusions of a cholecystokinin-pancreozymin preparation (Johnson and Magee, 1965). Secretin extracts did not alter gastric motility. It was suggested that the cholecystokinin-pancreozymin preparation contains the physiological activity
منابع مشابه
Effect of cholecystokinin-pancreozymin and secretin on the volume, composition, and enzymatic activity of hepatic bile in rabbits.
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Both secretin, and the single substance which possesses both cholecystokinin and pancreozymin activity, have been shown to inhibit gastric acid secretory responses. Since potentiation may occur between pairs of stimulants of gastric secretion, the effects of combining secretin and cholecystokinin/pancreozymin have been studied in Heidenhain pouches stimulated by continuous intravenous pentagast...
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Rats equipped with biliary, duodenal, and vena cava cannulae and supplemented with Na taurocholate received 4 hour infusions of gastrointestinal hormones. Boots secretin increased bile flow by 63% and bile acid, cholesterol, and phospholipid output by 75, 96, and 73% respectively. This stimulatory effect on bile flow and bile acid secretion was observed also in the four hour postinfusion period...
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تاریخ انتشار 2006